Gene: PAM
Alternate names for this Gene: PAL|PHM
Gene Summary: This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Gene is located in Chromosome: 5
Location in Chromosome : 5q21.1
Description of this Gene: peptidylglycine alpha-amidating monooxygenase
Type of Gene: protein-coding