Gene: PARVB

Alternate names for this Gene: CGI-56

Gene Summary: This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants.

Gene is located in Chromosome: 22

Location in Chromosome : 22q13.31

Description of this Gene: parvin beta

Type of Gene: protein-coding

rs75617873 in PARVB gene and Alzheimer's Disease PMID 23535033 2014 Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.

rs130318 in PARVB gene and Breast Carcinoma PMID 25117820 2014 Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100.

rs9614326 in PARVB gene and Cerebral Hemorrhage PMID 29915124 2018 17p12 Influences Hematoma Volume and Outcome in Spontaneous Intracerebral Hemorrhage.

rs12485168 in PARVB gene and RDW - Red blood cell distribution width result PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs12485168 in PARVB gene and Red cell distribution width determination PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.