Gene: PBRM1

Alternate names for this Gene: BAF180|PB1

Gene Summary: This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma.

Gene is located in Chromosome: 3

Location in Chromosome : 3p21.1

Description of this Gene: polybromo 1

Type of Gene: protein-coding

Gene: GNL3

Alternate names for this Gene: C77032|E2IG3|NNP47|NS

Gene Summary: The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene.

Gene is located in Chromosome: 3

Location in Chromosome : 3p21.1

Description of this Gene: G protein nucleolar 3

Type of Gene: protein-coding

rs10865974 in PBRM1;GNL3 gene and Bipolar Disorder PMID 22182935 2013 Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.

rs10865974 in PBRM1;GNL3 gene and Major Depressive Disorder PMID 22472876 2013 A mega-analysis of genome-wide association studies for major depressive disorder.