Gene: PBRM1

Alternate names for this Gene: BAF180|PB1

Gene Summary: This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma.

Gene is located in Chromosome: 3

Location in Chromosome : 3p21.1

Description of this Gene: polybromo 1

Type of Gene: protein-coding

Gene: SMIM4

Alternate names for this Gene: C3orf78

Gene Summary:

Gene is located in Chromosome: 3

Location in Chromosome : 3p21.1

Description of this Gene: small integral membrane protein 4

Type of Gene: protein-coding

rs11714565 in PBRM1;SMIM4 gene and Bipolar Disorder PMID 22182935 2013 Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.

rs2878628 in PBRM1;SMIM4 gene and Intelligence PMID 29326435 2019 A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.

rs11714565 in PBRM1;SMIM4 gene and Major Depressive Disorder PMID 22472876 2013 A mega-analysis of genome-wide association studies for major depressive disorder.