Gene: PDE7B

Alternate names for this Gene: bA472E5.1

Gene Summary: The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.

Gene is located in Chromosome: 6

Location in Chromosome : 6q23.3

Description of this Gene: phosphodiesterase 7B

Type of Gene: protein-coding

rs3799385 in PDE7B gene and Adolescent idiopathic scoliosis PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs17835714 in PDE7B gene and Aspartate aminotransferase measurement PMID 31219225 2019 Genome-Wide Association Study Identifies Loci for Liver Enzyme Concentrations in Mexican Americans: The GUARDIAN Consortium.

rs149647891 in PDE7B gene and Childhood asthma PMID 29551627 2018 Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study.

rs149647891 in PDE7B gene and Cortisol Measurement PMID 29551627 2018 Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study.

rs761545809 in PDE7B gene and Diverticulitis PMID 28585551 2017 Sequence variants in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis.

rs9494457 in PDE7B gene and Glaucoma PMID 30054594 2018 Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma.

rs3757155 in PDE7B gene and Glaucoma, Open-Angle PMID 29891935 2018 A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci.

rs3823159 in PDE7B gene and Narcolepsy PMID 19629137 2009 Genome-wide association database developed in the Japanese Integrated Database Project.

rs3799385 in PDE7B gene and SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs4896199 in PDE7B gene and Tonometry PMID 29617998 2018 Genome-wide association analyses identify new loci influencing intraocular pressure.

PMID 30054594 2018 Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma.

PMID 29785010 2018 Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma.