Gene: PIGU
Alternate names for this Gene: CDC91L1|GAB1|GPIBD21|NEDBSS
Gene Summary: The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins.
Gene is located in Chromosome: 20
Location in Chromosome : 20q11.22
Description of this Gene: phosphatidylinositol glycan anchor biosynthesis class U
Type of Gene: protein-coding
rs6058093 in
PIGU gene and
Adenocarcinoma of large intestine
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs6058093 in
PIGU gene and
Adenoma of large intestine
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs6087613 in
PIGU gene and
Body Height
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
rs7261964 in
PIGU gene and
Body Weight
PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.
rs6058093 in
PIGU gene and
COLORECTAL CANCER, SUSCEPTIBILITY TO, 1
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs6058093 in
PIGU gene and
COLORECTAL CANCER, SUSCEPTIBILITY TO, 10
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs6058093 in
PIGU gene and
COLORECTAL CANCER, SUSCEPTIBILITY TO, 12
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs6058093 in
PIGU gene and
COLORECTAL CANCER, SUSCEPTIBILITY TO, 3
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs6058093 in
PIGU gene and
Colorectal Carcinoma
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs6058093 in
PIGU gene and
Colorectal Neoplasms
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs6058093 in
PIGU gene and
Creatinine measurement, serum (procedure)
PMID 28452372 2017 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.
rs56238684 in
PIGU gene and
Cutaneous Melanoma
PMID 30429480 2018 Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.
rs6058093 in
PIGU gene and
Glomerular Filtration Rate
PMID 28452372 2017 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.
PMID 31152163 2019 A catalog of genetic loci associated with kidney function from analyses of a million individuals.
rs2424995 in
PIGU gene and
Hair Color
PMID 30531825 2018 Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability.
rs6059932 in
PIGU gene and
High density lipoprotein measurement
PMID 30289880 2018 Heritability informed power optimization (HIPO) leads to enhanced detection of genetic associations across multiple traits.
rs6059932 in
PIGU gene and
Low density lipoprotein cholesterol measurement
PMID 30289880 2018 Heritability informed power optimization (HIPO) leads to enhanced detection of genetic associations across multiple traits.
rs56238684 in
PIGU gene and
Malignant melanoma of skin of lower limb
PMID 30429480 2018 Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.
rs56238684 in
PIGU gene and
Malignant melanoma of skin of upper limb
PMID 30429480 2018 Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.
rs6058093 in
PIGU gene and
Malignant neoplasm of large intestine
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs6058093 in
PIGU gene and
Malignant tumor of colon
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs910873 in
PIGU gene and
Nasopharyngeal carcinoma
PMID 20512145 2010 A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.
rs6142206 in
PIGU gene and
Protein C antigen measurement
PMID 20802025 2010 Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study.
rs6142206 in
PIGU gene and
Protein C measurement
PMID 20802025 2010 Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study.
rs6059932 in
PIGU gene and
Serum total cholesterol measurement
PMID 30289880 2018 Heritability informed power optimization (HIPO) leads to enhanced detection of genetic associations across multiple traits.
rs56238684 in
PIGU gene and
Suntan
PMID 29739929 2018 Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure.
rs6059932 in
PIGU gene and
Triglycerides measurement
PMID 30289880 2018 Heritability informed power optimization (HIPO) leads to enhanced detection of genetic associations across multiple traits.
rs910873 in
PIGU gene and
melanoma
PMID 28212542 2017 Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma.
PMID 18488026 2008 Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)).