Gene: PLA2G12A

Alternate names for this Gene: GXII|PLA2G12|ROSSY

Gene Summary: Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008]. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this RefSeq transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.232034.1, SRR1660809.196392.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467150, SAMN03267778 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000243501.10/ ENSP00000243501.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

Gene is located in Chromosome: 4

Location in Chromosome : 4q25

Description of this Gene: phospholipase A2 group XIIA

Type of Gene: protein-coding