Gene: PPAN

Alternate names for this Gene: BXDC3|SSF|SSF-1|SSF1|SSF2

Gene Summary: The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (ppan). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and ppan are essential for cell growth and proliferation. Exogenous expression of this gene was reported to reduce the anchorage-independent growth of some tumor cells. Read-through transcription of this gene with P2RY11/P2Y(11), an adjacent downstream gene that encodes an ATP receptor, has been found. These read-through transcripts are ubiquitously present and up-regulated during granulocyte differentiation.

Gene is located in Chromosome: 19

Location in Chromosome : 19p13.2

Description of this Gene: peter pan homolog

Type of Gene: protein-coding

Gene: P2RY11

Alternate names for this Gene: P2Y11

Gene Summary: The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product.

Gene is located in Chromosome: 19

Location in Chromosome : 19p13.2

Description of this Gene: purinergic receptor P2Y11

Type of Gene: protein-coding

Gene: PPAN-P2RY11

Alternate names for this Gene: BXDC3|P2RY11|P2Y11|PPAN|SSF1|Ssf-1

Gene Summary: This locus represents naturally occurring read-through transcription between the adjacent PPAN and P2RY11 genes. Alternative splicing results in two transcript variants, one of which encodes a fusion protein that shares sequence identity with each individual gene product. This transcript is found to be ubiquitously expressed and is up-regulated by agents inducing granulocytic differentiation. However, its functional significance in vivo remains unclear.

Gene is located in Chromosome: 19

Location in Chromosome : 19p13.2

Description of this Gene: PPAN-P2RY11 readthrough

Type of Gene: protein-coding