Gene: PPP1R37

Alternate names for this Gene: LRRC68

Gene Summary:

Gene is located in Chromosome: 19

Location in Chromosome : 19q13.32

Description of this Gene: protein phosphatase 1 regulatory subunit 37

Type of Gene: protein-coding

Gene: MARK4

Alternate names for this Gene: MARK4L|MARK4S|MARKL1|MARKL1L|PAR-1D

Gene Summary: This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene is located in Chromosome: 19

Location in Chromosome : 19q13.32

Description of this Gene: microtubule affinity regulating kinase 4

Type of Gene: protein-coding

rs10409138 in PPP1R37;MARK4 gene and Adolescent idiopathic scoliosis PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs1048699 in PPP1R37;MARK4 gene and Alzheimer's Disease PMID 21460841 2011 Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

PMID 29777097 2018 GWAS on family history of Alzheimer's disease.

rs1048699 in PPP1R37;MARK4 gene and Autoantibody measurement PMID 19734900 2009 Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.

rs10409138 in PPP1R37;MARK4 gene and SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.