Gene: PRKAG1

Alternate names for this Gene: AMPKG

Gene Summary: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene is located in Chromosome: 12

Location in Chromosome : 12q13.12

Description of this Gene: protein kinase AMP-activated non-catalytic subunit gamma 1

Type of Gene: protein-coding

Gene: DDN-AS1

Alternate names for this Gene: CAT1507

Gene Summary:

Gene is located in Chromosome: 12

Location in Chromosome : 12q13.12

Description of this Gene: DDN and PRKAG1 antisense RNA 1

Type of Gene: ncRNA

rs1126930 in PRKAG1;DDN-AS1 gene and Body mass index PMID 29273807 2018 Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

rs1126930 in PRKAG1;DDN-AS1 gene and High density lipoprotein measurement PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.

rs1126930 in PRKAG1;DDN-AS1 gene and RDW - Red blood cell distribution width result PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs1126930 in PRKAG1;DDN-AS1 gene and Red cell distribution width determination PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs1126930 in PRKAG1;DDN-AS1 gene and Systolic Pressure PMID 27618447 2016 Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 30578418 2019 Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

rs2293445 in PRKAG1;DDN-AS1 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.