Gene: PSCA

Alternate names for this Gene: PRO232

Gene Summary: This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 8

Location in Chromosome : 8q24.3

Description of this Gene: prostate stem cell antigen

Type of Gene: protein-coding

Gene: JRK

Alternate names for this Gene: JH8|jerky

Gene Summary: This gene encodes a conserved protein that is similar to DNA-binding proteins, such as major centromere autoantigen B (CENPB). Inactivation of the related gene in mice resulted in epileptic seizures. Childhood Absence Epilepsy (CAE) has been mapped to the same chromosomal location (8q24.3) as this gene. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 8

Location in Chromosome : 8q24.3

Description of this Gene: Jrk helix-turn-helix protein

Type of Gene: protein-coding

rs2978981 in PSCA;JRK gene and Blood urea nitrogen measurement PMID 31152163 2019 A catalog of genetic loci associated with kidney function from analyses of a million individuals.

rs2294008 in PSCA;JRK gene and Carcinoma of bladder PMID 24163127 2014 Genome-wide association study identifies multiple loci associated with bladder cancer risk.

PMID 19648920 2009 Our data identify rs2294008 as a new bladder cancer susceptibility locus.

PMID 20972438 2010 A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.

rs2294008 in PSCA;JRK gene and Duodenal Ulcer PMID 22387998 2012 The T allele of rs2294008 encodes a translation initiation codon upstream of the reported site and changes protein localization from the cytoplasm to the cell surface. rs505922 at ABO was also associated with duodenal ulcer in a recessive model (OR = 1.32; P = 1.15 × 10(-10)).

PMID 22387998 2012 A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population.

rs2294008 in PSCA;JRK gene and Gastric Adenocarcinoma PMID 26098866 2015 Loss-of-function variants in ATM confer risk of gastric cancer.

rs2294008 in PSCA;JRK gene and Gastritis, Atrophic PMID 30753327 2019 GWAS analysis reveals a significant contribution of PSCA to the risk of Heliobacter pylori-induced gastric atrophy.

rs2294008 in PSCA;JRK gene and Malignant neoplasm of urinary bladder PMID 19648920 2009 Our data identify rs2294008 as a new bladder cancer susceptibility locus.

PMID 20972438 2010 A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.

rs2294008 in PSCA;JRK gene and Nasopharyngeal carcinoma PMID 20512145 2010 A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.

rs72690918 in PSCA;JRK gene and Smoking PMID 26053186 2015 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.

rs72690918 in PSCA;JRK gene and Smoking Behaviors PMID 26053186 2015 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.

rs2294008 in PSCA;JRK gene and Stomach Carcinoma PMID 26701879 2017 Identification of new susceptibility loci for gastric non-cardia adenocarcinoma: pooled results from two Chinese genome-wide association studies.

PMID 26098866 2015 Loss-of-function variants in ATM confer risk of gastric cancer.

PMID 30281874 2018 Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21.