Gene: RAD51C
Alternate names for this Gene: BROVCA3|FANCO|R51H3|RAD51L2
Gene Summary: This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants.
Gene is located in Chromosome: 17
Location in Chromosome : 17q22
Description of this Gene: RAD51 paralog C
Type of Gene: protein-coding
Gene: TEX14
Alternate names for this Gene: CT113|SPGF23
Gene Summary: The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.
Gene is located in Chromosome: 17
Location in Chromosome : 17q22
Description of this Gene: testis expressed 14, intercellular bridge forming factor
Type of Gene: protein-coding
rs587782528 in
RAD51C;TEX14 gene and
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3
PMID 26261251 2015 Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.
PMID 26689913 2015 Patterns and functional implications of rare germline variants across 12 cancer types.
PMID 26681312 2016 Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing.
PMID 21616938 2011 RAD51C is a susceptibility gene for ovarian cancer.
rs587782528 in
RAD51C;TEX14 gene and
FANCONI ANEMIA, COMPLEMENTATION GROUP O
PMID 26261251 2015 Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.
PMID 26689913 2015 Patterns and functional implications of rare germline variants across 12 cancer types.
PMID 26681312 2016 Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing.
PMID 27433846 2016 Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer.
PMID 21616938 2011 RAD51C is a susceptibility gene for ovarian cancer.
PMID 24800917 2014 Deleterious RAD51C germline mutations rarely predispose to breast and ovarian cancer in Pakistan.
PMID 21990120 2012 Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients.
PMID 20400964 2010 Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene.
rs587782528 in
RAD51C;TEX14 gene and
Hereditary Breast and Ovarian Cancer Syndrome
PMID 26261251 2015 Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.
PMID 21616938 2011 RAD51C is a susceptibility gene for ovarian cancer.
rs587782528 in
RAD51C;TEX14 gene and
Neoplastic Syndromes, Hereditary
PMID 26261251 2015 Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.
PMID 26681312 2016 Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing.
PMID 21616938 2011 RAD51C is a susceptibility gene for ovarian cancer.
PMID 27433846 2016 Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer.
PMID 25470109 2015 Genetic testing for RAD51C mutations: in the clinic and community.
PMID 23176254 2012 Screening of Finnish RAD51C founder mutations in prostate and colorectal cancer patients.
PMID 20400964 2010 Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene.
PMID 24993905 2014 Pathological features of breast and ovarian cancers in RAD51C germline mutation carriers.