Gene: RASGRF2

Alternate names for this Gene: GRF2|RAS-GRF2

Gene Summary: RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways.

Gene is located in Chromosome: 5

Location in Chromosome : 5q14.1

Description of this Gene: Ras protein specific guanine nucleotide releasing factor 2

Type of Gene: protein-coding

rs17211233 in RASGRF2 gene and Bipolar Disorder PMID 30552317 2018 Exploratory genome-wide association analysis of response to ketamine and a polygenic analysis of response to scopolamine in depression.

rs10491487 in RASGRF2 gene and Dementia, Vascular PMID 22116812 2012 Genome-wide association study of vascular dementia.

rs138206701 in RASGRF2 gene and Eating Disorders PMID 23568457 2013 Genetic variants associated with disordered eating.

rs17211233 in RASGRF2 gene and Major Depressive Disorder PMID 30552317 2018 Exploratory genome-wide association analysis of response to ketamine and a polygenic analysis of response to scopolamine in depression.

rs138206701 in RASGRF2 gene and Other eating disorders PMID 23568457 2013 Genetic variants associated with disordered eating.

rs13357015 in RASGRF2 gene and Smoking PMID 30643258 2019 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.

rs17211233 in RASGRF2 gene and Unipolar Depression PMID 30552317 2018 Exploratory genome-wide association analysis of response to ketamine and a polygenic analysis of response to scopolamine in depression.

rs17211233 in RASGRF2 gene and response to ketamine PMID 30552317 2018 Exploratory genome-wide association analysis of response to ketamine and a polygenic analysis of response to scopolamine in depression.