Gene: RBM5

Alternate names for this Gene: G15|H37|LUCA-15|LUCA15|RMB5

Gene Summary: This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer.

Gene is located in Chromosome: 3

Location in Chromosome : 3p21.31

Description of this Gene: RNA binding motif protein 5

Type of Gene: protein-coding

Gene: RBM6

Alternate names for this Gene: 3G2|DEF-3|DEF3|HLC-11|NY-LU-12|g16

Gene Summary:

Gene is located in Chromosome: 3

Location in Chromosome : 3p21.31

Description of this Gene: RNA binding motif protein 6

Type of Gene: protein-coding

rs2013208 in RBM5;RBM6 gene and Alcohol consumption PMID 30698716 2019 Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.

rs2013208 in RBM5;RBM6 gene and High density lipoprotein measurement PMID 24097068 2013 Discovery and refinement of loci associated with lipid levels.

PMID 28334899 2017 Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.

PMID 30698716 2019 Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.

rs2013208 in RBM5;RBM6 gene and Intelligence PMID 29942086 2018 Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.

rs2013208 in RBM5;RBM6 gene and Serum HDL cholesterol measurement PMID 24097068 2013 Discovery and refinement of loci associated with lipid levels.