Gene: ROS1

Alternate names for this Gene: MCF3|ROS|c-ros-1

Gene Summary: This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor.

Gene is located in Chromosome: 6

Location in Chromosome : 6q22.1

Description of this Gene: ROS proto-oncogene 1, receptor tyrosine kinase

Type of Gene: protein-coding

rs1057519788 in ROS1 gene and Adenocarcinoma of lung (disorder) PMID 23724914 2013 Acquired resistance to crizotinib from a mutation in CD74-ROS1.

rs6913494 in ROS1 gene and Adolescent idiopathic scoliosis PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs210966 in ROS1 gene and Creatine kinase measurement PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

rs17632578 in ROS1 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

rs210967 in ROS1 gene and Meningitis, Pneumococcal PMID 31092817 2019 Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis.

rs6913494 in ROS1 gene and SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.