Gene: RSPO1
Alternate names for this Gene: CRISTIN3|RSPO
Gene Summary: This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants.
Gene is located in Chromosome: 1
Location in Chromosome : 1p34.3
Description of this Gene: R-spondin 1
Type of Gene: protein-coding