Gene: SCN10A

Alternate names for this Gene: FEPS2|Nav1.8|PN3|SNS

Gene Summary: The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 3

Location in Chromosome : 3p22.2

Description of this Gene: sodium voltage-gated channel alpha subunit 10

Type of Gene: protein-coding

rs6790396 in SCN10A gene and Atrial Fibrillation PMID 30061737 2018 Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.

PMID 29892015 2018 Multi-ethnic genome-wide association study for atrial fibrillation.

rs10428132 in SCN10A gene and Brugada Syndrome (disorder) PMID 23872634 2013 Through a genome-wide association study of 312 individuals with Brugada syndrome and 1,115 controls, we detected 2 significant association signals at the SCN10A locus (rs10428132) and near the HEY2 gene (rs9388451).

PMID 23872634 2013 Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.

rs138404783 in SCN10A gene and EPISODIC PAIN SYNDROME, FAMILIAL, 2 PMID 23115331 2012 Gain-of-function Nav1.8 mutations in painful neuropathy.

rs4076737 in SCN10A gene and Electrocardiogram: P-R interval PMID 21347284 2011 Genome-wide association studies of the PR interval in African Americans.

PMID 30046033 2018 PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.

PMID 20062063 2010 Several common variants modulate heart rate, PR interval and QRS duration.

PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.

PMID 20062061 2010 Replication testing among 6,243 Indian Asians and 5,370 Europeans confirmed that rs6795970 (G>A) is associated with prolonged cardiac conduction (longer P-wave duration, PR interval and QRS duration, P = 10(-5) to 10(-20)).

PMID 20062060 2010 Genome-wide association study of PR interval.

PMID 30679814 2019 Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits.

PMID 25055868 2014 Genome-wide association study of electrocardiographic parameters identifies a new association for PR interval and confirms previously reported associations.

PMID 23139255 2012 Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.

PMID 29127183 2018 Genome-wide association study of PR interval in Hispanics/Latinos identifies novel locus at ID2.

PMID 25035420 2014 Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.

rs6795970 in SCN10A gene and Electrocardiography PMID 20062061 2010 Genetic variation in SCN10A influences cardiac conduction.

rs6800541 in SCN10A gene and Heart Function Tests PMID 21041692 2010 Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science.

PMID 21076409 2010 Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.

rs6790396 in SCN10A gene and P wave duration (observable entity) PMID 28794112 2017 Fifteen Genetic Loci Associated With the Electrocardiographic P Wave.

PMID 24850809 2014 Genetic determinants of P wave duration and PR segment.

rs6795970 in SCN10A gene and QRS complex feature PMID 20062063 2010 Several common variants modulate heart rate, PR interval and QRS duration.

PMID 27659466 2016 52 Genetic Loci Influencing Myocardial Mass.

rs6801957 in SCN10A gene and QT interval feature (observable entity) PMID 24952745 2014 Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.

rs6599255 in SCN10A gene and RESTING HEART RATE PMID 27798624 2016 Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.