Gene: SELP

Alternate names for this Gene: CD62|CD62P|GMP140|GRMP|LECAM3|PADGEM|PSEL

Gene Summary: This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented.

Gene is located in Chromosome: 1

Location in Chromosome : 1q24.2

Description of this Gene: selectin P

Type of Gene: protein-coding

rs2205895 in SELP gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

PMID 30111768 2018 Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease.

rs3917781 in SELP gene and High density lipoprotein measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs6136 in SELP gene and P-Selectin Measurement PMID 28240269 2017 Connecting genetic risk to disease end points through the human blood plasma proteome.

rs3917781 in SELP gene and Serum HDL cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs3917831 in SELP gene and Serum total cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs2235302 in SELP gene and Soluble P-Selectin Measurement PMID 20167578 2010 Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels.

rs3917693 in SELP gene and Venous Thrombosis PMID 22675575 2012 Caution in interpreting results from imputation analysis when linkage disequilibrium extends over a large distance: a case study on venous thrombosis.