Gene: SH2B3
Alternate names for this Gene: IDDM20|LNK
Gene Summary: This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene is located in Chromosome: 12
Location in Chromosome : 12q24.12
Description of this Gene: SH2B adaptor protein 3
Type of Gene: protein-coding