Gene: SLC14A2

Alternate names for this Gene: HUT2|UT-A2|UT2|UTA|UTR|hUT-A6

Gene Summary: The protein encoded by this gene belongs to the urea transporter family. In mammalian cells, urea is the chief end product of nitrogen catabolism, and plays an important role in the urinary concentration mechanism. This protein is expressed in the inner medulla of the kidney, and mediates rapid transepithelial urea transport across the inner medullary collecting duct. Alternatively spliced transcript variants have been found for this gene.

Gene is located in Chromosome: 18

Location in Chromosome : 18q12.3

Description of this Gene: solute carrier family 14 member 2

Type of Gene: protein-coding

rs2243803 in SLC14A2 gene and Age at menarche PMID 21102462 2010 Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.

rs10502861 in SLC14A2 gene and Alopecia PMID 28196072 2017 Genetic prediction of male pattern baldness.

rs10502861 in SLC14A2 gene and Alopecia, Androgenetic, 1 PMID 22693459 2012 Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.

PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

PMID 29146897 2017 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

rs10502861 in SLC14A2 gene and Alopecia, Androgenetic, 2 PMID 22693459 2012 Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.

PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

PMID 29146897 2017 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

rs10502861 in SLC14A2 gene and Alopecia, Androgenetic, 3 PMID 22693459 2012 Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.

PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

PMID 29146897 2017 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

rs10502861 in SLC14A2 gene and Alopecia, Male Pattern PMID 22693459 2012 Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.

PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

PMID 29146897 2017 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

rs10502861 in SLC14A2 gene and Androgenetic Alopecia PMID 22693459 2012 Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.

PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

PMID 29146897 2017 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

rs1484873 in SLC14A2 gene and Blood urea nitrogen measurement PMID 31152163 2019 A catalog of genetic loci associated with kidney function from analyses of a million individuals.

PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

rs10438964 in SLC14A2 gene and Body mass index PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

rs9952980 in SLC14A2 gene and Breast Carcinoma PMID 29059683 2017 Association analysis identifies 65 new breast cancer risk loci.

rs2543029 in SLC14A2 gene and Diastolic blood pressure PMID 30578418 2019 Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

rs9807668 in SLC14A2 gene and Forced expiratory volume function PMID 30804560 2019 New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

rs11082438 in SLC14A2 gene and Mature B-Cell Neoplasm PMID 25279986 2014 Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region.

rs10502861 in SLC14A2 gene and Other alopecia PMID 22693459 2012 Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.

PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

PMID 29146897 2017 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

rs2705366 in SLC14A2 gene and Red Blood Cell Count measurement PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs7232775 in SLC14A2 gene and Serum albumin measurement PMID 21909109 2011 Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.

rs2193635 in SLC14A2 gene and Systolic Pressure PMID 27841878 2017 Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs7232775 in SLC14A2 gene and Uric acid measurement (procedure) PMID 21909109 2011 Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.

rs9807668 in SLC14A2 gene and Vital capacity PMID 30804560 2019 New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.