Gene: SLC16A7

Alternate names for this Gene: MCT2

Gene Summary: This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 12

Location in Chromosome : 12q14.1

Description of this Gene: solute carrier family 16 member 7

Type of Gene: protein-coding

rs7303876 in SLC16A7 gene and Alzheimer's Disease PMID 20885792 2010 Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.

rs7976838 in SLC16A7 gene and Asthma PMID 26031901 2016 Genome-wide association study of leukotriene modifier response in asthma.

rs1000708 in SLC16A7 gene and Proliferative diabetic retinopathy PMID 30487263 2019 Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control.