Gene: SLC22A4

Alternate names for this Gene: DFNB60|OCTN1

Gene Summary: Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent.

Gene is located in Chromosome: 5

Location in Chromosome : 5q31.1

Description of this Gene: solute carrier family 22 member 4

Type of Gene: protein-coding

Gene: MIR3936HG

Alternate names for this Gene:

Gene Summary:

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Description of this Gene:

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rs270601 in SLC22A4;MIR3936HG gene and Acylcarnitines measurement PMID 26068415 2015 Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels.

rs273909 in SLC22A4;MIR3936HG gene and Coronary Artery Disease PMID 29212778 2018 Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.

PMID 23202125 2013 Large-scale association analysis identifies new risk loci for coronary artery disease.

rs1050152 in SLC22A4;MIR3936HG gene and Crohn Disease PMID 17804789 2007 Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.

rs272889 in SLC22A4;MIR3936HG gene and Glucose measurement PMID 21886157 2011 Human metabolic individuality in biomedical and pharmaceutical research.

rs56399423 in SLC22A4;MIR3936HG gene and Inflammatory Bowel Diseases PMID 26192919 2015 Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.

rs1050152 in SLC22A4;MIR3936HG gene and Nasal Polyps PMID 30643255 2019 A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.

rs538021413 in SLC22A4;MIR3936HG gene and Reticulocyte count (procedure) PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs272869 in SLC22A4;MIR3936HG gene and Smoking PMID 28443625 2017 Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

rs272869 in SLC22A4;MIR3936HG gene and Smoking Behaviors PMID 28443625 2017 Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

rs272889 in SLC22A4;MIR3936HG gene and elevated blood glucose level PMID 21886157 2011 Human metabolic individuality in biomedical and pharmaceutical research.