Gene: SLC2A2

Alternate names for this Gene: GLUT2

Gene Summary: This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene.

Gene is located in Chromosome: 3

Location in Chromosome : 3q26.2

Description of this Gene: solute carrier family 2 member 2

Type of Gene: protein-coding

rs11920090 in SLC2A2 gene and Body mass index PMID 22581228 2012 A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.

PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs66733022 in SLC2A2 gene and C-reactive protein measurement PMID 30388399 2018 Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.

rs8192675 in SLC2A2 gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 28566273 2017 An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.

PMID 27500523 2016 Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.

rs121909743 in SLC2A2 gene and Fanconi-Bickel Syndrome PMID 27487919 2016 Fanconi-Bickel syndrome in two Palestinian children: marked phenotypic variability with identical mutation.

PMID 24718840 2015 Phenotypic variability in patients with fanconi-bickel syndrome with identical mutations.

PMID 11810292 2002 The mutation spectrum of the facilitative glucose transporter gene SLC2A2 (GLUT2) in patients with Fanconi-Bickel syndrome.

PMID 22145468 2011 Two cases of Fanconi-Bickel syndrome: first report from China with novel mutations of SLC2A2 gene.

PMID 11044475 2000 Mutation analysis of the GLUT2 gene in patients with Fanconi-Bickel syndrome.

PMID 10987651 1999 A mutation in GLUT2, not in phosphorylase kinase subunits, in hepato-renal glycogenosis with Fanconi syndrome and low phosphorylase kinase activity.

PMID 25919556 2015 [SLC2A2 gene analysis in three Chinese children with Fanconi-Bickel syndrome].

rs11920090 in SLC2A2 gene and Fasting blood glucose measurement PMID 25631608 2015 Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.

PMID 22885924 2012 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.

PMID 22581228 2012 A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.

PMID 20081858 2010 New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.

PMID 28270201 2017 Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants.

rs11920090 in SLC2A2 gene and Fasting blood sugar result PMID 22885924 2012 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.

rs11924032 in SLC2A2 gene and Glucose measurement PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

rs10513686 in SLC2A2 gene and Serum gamma-glutamyl transferase measurement PMID 22001757 2011 Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.

rs11720145 in SLC2A2 gene and Triglycerides measurement PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.

rs11924032 in SLC2A2 gene and elevated blood glucose level PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.