Gene: SLC30A8

Alternate names for this Gene: ZNT8|ZnT-8

Gene Summary: The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 8

Location in Chromosome : 8q24.11

Description of this Gene: solute carrier family 30 member 8

Type of Gene: protein-coding

rs3019885 in SLC30A8 gene and Aortic Aneurysm, Abdominal PMID 22055160 2011 Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1.

rs3019885 in SLC30A8 gene and Asthma PMID 21814517 2011 Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations.

rs531347476 in SLC30A8 gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 30718926 2019 Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.

PMID 29703844 2018 A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.

rs6997279 in SLC30A8 gene and Diabetic Nephropathy PMID 29703844 2018 A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.

rs6997279 in SLC30A8 gene and Kidney Failure, Chronic PMID 29703844 2018 A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.

rs1155178 in SLC30A8 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.