Gene: SLC4A8

Alternate names for this Gene: NBC3|NDCBE

Gene Summary: The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 12

Location in Chromosome : 12q13.13

Description of this Gene: solute carrier family 4 member 8

Type of Gene: protein-coding

rs147845115 in SLC4A8 gene and Alzheimer's Disease PMID 23535033 2014 Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.