Gene: SMYD3

Alternate names for this Gene: KMT3E|ZMYND1|ZNFN3A1|bA74P14.1

Gene Summary: This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 1

Location in Chromosome : 1q44

Description of this Gene: SET and MYND domain containing 3

Type of Gene: protein-coding

rs10924690 in SMYD3 gene and Central Nervous System Neoplasms PMID 19578366 2009 Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility.

rs10924690 in SMYD3 gene and Glioma PMID 19578366 2009 Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility.

rs7512924 in SMYD3 gene and Impaired cognition PMID 31201950 2019 Analysis of pleiotropic genetic effects on cognitive impairment, systemic inflammation, and plasma lipids in the Health and Retirement Study.

rs10754479 in SMYD3 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

rs1780813 in SMYD3 gene and Lupus Erythematosus, Systemic PMID 29848360 2018 Genome-wide association study meta-analysis identifies five new loci for systemic lupus erythematosus.