Gene: SNX9

Alternate names for this Gene: SDP1|SH3PX1|SH3PXD3A|WISP

Gene Summary: This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region, like some family members, but does contain a SRC homology domain near its N-terminus. The encoded protein is reported to have a variety of interaction partners, including of adaptor protein 2 , dynamin, tyrosine kinase non-receptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded protein is implicated in several stages of intracellular trafficking, including endocytosis, macropinocytosis, and F-actin nucleation.

Gene is located in Chromosome: 6

Location in Chromosome : 6q25.3

Description of this Gene: sorting nexin 9

Type of Gene: protein-coding

rs34804891 in SNX9 gene and Alzheimer's Disease PMID 26830138 2016 Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3.

rs11754196 in SNX9 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

rs9346930 in SNX9 gene and Lipoprotein (a) measurement PMID 25575512 2015 Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels.

rs71826849 in SNX9 gene and Platelet Component Distribution Width Measurement PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs2364349 in SNX9 gene and heart rate PMID 29478026 2018 Genome-Wide Association Approach Identified Novel Genetic Predictors of Heart Rate Response to β-Blockers.