Gene: SOX2-OT

Alternate names for this Gene: NCRNA00043|SOX2OT

Gene Summary: This gene produces alternatively spliced long non-coding RNAs. These RNAs were observed to be upregulated in tumor cells and positively correlated to expression of the SRY-box 2 gene. Overexpression of these transcripts may promote cell proliferation.

Gene is located in Chromosome: 3

Location in Chromosome : 3q26.33

Description of this Gene: SOX2 overlapping transcript

Type of Gene: ncRNA

rs9839776 in SOX2-OT gene and Anorexia Nervosa PMID 24514567 2014 A genome-wide association study of anorexia nervosa.

rs13086738 in SOX2-OT gene and Bipolar Disorder PMID 26433762 2016 A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region.

rs4133078 in SOX2-OT gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs1805207 in SOX2-OT gene and Body mass index PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

rs13086738 in SOX2-OT gene and Eating Disorders PMID 26433762 2016 A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region.

PMID 26433762 2016 The most significant genome-wide finding was observed bipolar with comorbid eating disorder vs. controls within SOX2-OT (p=8.9×10(-8) for rs4854912) with a secondary peak in the adjacent FXR1 gene (p=1.2×10(-6) for rs1805576) on chromosome 3q26.33.

rs1345417 in SOX2-OT gene and Hirsutism PMID 29895819 2018 Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations.

rs2216428 in SOX2-OT gene and Intelligence PMID 29844566 2018 Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

rs13086738 in SOX2-OT gene and Other eating disorders PMID 26433762 2016 A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region.

rs1878874 in SOX2-OT gene and Schizophrenia PMID 26198764 2015 Genome-wide association study of schizophrenia in Ashkenazi Jews.

PMID 30285260 2019 Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.

PMID 25056061 2014 Biological insights from 108 schizophrenia-associated genetic loci.

PMID 28991256 2017 Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia.