Gene: SP6

Alternate names for this Gene: EPFN|EPIPROFIN|KLF14

Gene Summary: SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008].

Gene is located in Chromosome: 17

Location in Chromosome : 17q21.32

Description of this Gene: Sp6 transcription factor

Type of Gene: protein-coding

rs4794202 in SP6 gene and Alzheimer's Disease PMID 23535033 2014 Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.

rs72833466 in SP6 gene and Hair Color PMID 30531825 2018 Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability.