Gene: SPC25

Alternate names for this Gene: AD024|SPBC25|hSpc25

Gene Summary: This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity.

Gene is located in Chromosome: 2

Location in Chromosome : 2q24.3

Description of this Gene: SPC25 component of NDC80 kinetochore complex

Type of Gene: protein-coding

Gene: NOSTRIN

Alternate names for this Gene: DaIP2

Gene Summary: Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004].

Gene is located in Chromosome: 2

Location in Chromosome : 2q24.3

Description of this Gene: nitric oxide synthase trafficking

Type of Gene: protein-coding

rs566465 in SPC25;NOSTRIN gene and Age at menarche PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs139707092 in SPC25;NOSTRIN gene and Blood basophil count (lab test) PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs139707092 in SPC25;NOSTRIN gene and Eosinophil count procedure PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs139707092 in SPC25;NOSTRIN gene and Granulocyte count PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs139707092 in SPC25;NOSTRIN gene and Neutrophil count (procedure) PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs139707092 in SPC25;NOSTRIN gene and White Blood Cell Count procedure PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.