Gene: SYK

Alternate names for this Gene: p72-Syk

Gene Summary: This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 9

Location in Chromosome : 9q22.2

Description of this Gene: spleen associated tyrosine kinase

Type of Gene: protein-coding

rs290227 in SYK gene and Dementia, Vascular PMID 23480133 2013 We suggested a novel association of the VaD susceptibility with an intronic variant of rs290227 in the SYK gene.

rs290986 in SYK gene and High density lipoprotein measurement PMID 26920376 2016 Genetic overlap between multiple sclerosis and several cardiovascular disease risk factors.

rs10821515 in SYK gene and Malignant neoplasm of esophagus PMID 21642993 2011 Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.

rs290986 in SYK gene and Multiple Sclerosis PMID 26920376 2016 Genetic overlap between multiple sclerosis and several cardiovascular disease risk factors.

PMID 21833088 2011 Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

rs2780701 in SYK gene and Platelet Component Distribution Width Measurement PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.