Gene: SYMPK

Alternate names for this Gene: SPK|SYM

Gene Summary: This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types.

Gene is located in Chromosome: 19

Location in Chromosome : 19q13.32

Description of this Gene: symplekin

Type of Gene: protein-coding

rs56848936 in SYMPK gene and Adenocarcinoma of large intestine PMID 28295283 2017 Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans.

rs7254067 in SYMPK gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs56848936 in SYMPK gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 PMID 28295283 2017 Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans.

rs56848936 in SYMPK gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 10 PMID 28295283 2017 Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans.

rs56848936 in SYMPK gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 12 PMID 28295283 2017 Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans.

rs56848936 in SYMPK gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 3 PMID 28295283 2017 Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans.

rs56848936 in SYMPK gene and Colonic Neoplasms PMID 28295283 2017 Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans.

rs56848936 in SYMPK gene and Colorectal Carcinoma PMID 28295283 2017 Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans.

rs56848936 in SYMPK gene and Colorectal Neoplasms PMID 28295283 2017 Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans.

rs62109854 in SYMPK gene and Eosinophil count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs10500292 in SYMPK gene and Fasting blood glucose measurement PMID 22885924 2012 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.

rs10500292 in SYMPK gene and Fasting blood sugar result PMID 22885924 2012 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.

rs56848936 in SYMPK gene and Malignant neoplasm of large intestine PMID 28295283 2017 Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans.

rs56848936 in SYMPK gene and Malignant tumor of colon PMID 28295283 2017 We identified a novel variant, rs56848936 in the gene SYMPK at 19q13.3, associated with colon cancer risk (odds ratio 0.61 for the risk allele G, p = 2.4 × 10<sup>-8</sup> ).

rs8102876 in SYMPK gene and Systolic Pressure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.