Gene: SYMPK
Alternate names for this Gene: SPK|SYM
Gene Summary: This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types.
Gene is located in Chromosome: 19
Location in Chromosome : 19q13.32
Description of this Gene: symplekin
Type of Gene: protein-coding
rs56848936 in
SYMPK gene and
Adenocarcinoma of large intestine
PMID 28295283 2017 Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans.
rs7254067 in
SYMPK gene and
Body Height
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
rs56848936 in
SYMPK gene and
COLORECTAL CANCER, SUSCEPTIBILITY TO, 1
PMID 28295283 2017 Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans.
rs56848936 in
SYMPK gene and
COLORECTAL CANCER, SUSCEPTIBILITY TO, 10
PMID 28295283 2017 Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans.
rs56848936 in
SYMPK gene and
COLORECTAL CANCER, SUSCEPTIBILITY TO, 12
PMID 28295283 2017 Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans.
rs56848936 in
SYMPK gene and
COLORECTAL CANCER, SUSCEPTIBILITY TO, 3
PMID 28295283 2017 Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans.
rs56848936 in
SYMPK gene and
Colonic Neoplasms
PMID 28295283 2017 Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans.
rs56848936 in
SYMPK gene and
Colorectal Carcinoma
PMID 28295283 2017 Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans.
rs56848936 in
SYMPK gene and
Colorectal Neoplasms
PMID 28295283 2017 Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans.
rs62109854 in
SYMPK gene and
Eosinophil count procedure
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
rs10500292 in
SYMPK gene and
Fasting blood glucose measurement
PMID 22885924 2012 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
rs10500292 in
SYMPK gene and
Fasting blood sugar result
PMID 22885924 2012 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
rs56848936 in
SYMPK gene and
Malignant neoplasm of large intestine
PMID 28295283 2017 Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans.
rs56848936 in
SYMPK gene and
Malignant tumor of colon
PMID 28295283 2017 We identified a novel variant, rs56848936 in the gene SYMPK at 19q13.3, associated with colon cancer risk (odds ratio 0.61 for the risk allele G, p = 2.4 × 10<sup>-8</sup> ).
rs8102876 in
SYMPK gene and
Systolic Pressure
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.