Gene: TMEM258
Alternate names for this Gene:
Gene Summary:
Gene is located in Chromosome:
Location in Chromosome :
Description of this Gene:
Type of Gene:
Gene: MYRF
Alternate names for this Gene: 11orf9|C11orf9|CUGS|MMERV|MRF|Ndt80|pqn-47
Gene Summary: This gene encodes a transcription factor that is required for central nervous system myelination and may regulate oligodendrocyte differentiation. It is thought to act by increasing the expression of genes that effect myelin production but may also directly promote myelin gene expression. Loss of a similar gene in mouse models results in severe demyelination. Alternative splicing results in multiple transcript variants.
Gene is located in Chromosome: 11
Location in Chromosome : 11q12.2
Description of this Gene: myelin regulatory factor
Type of Gene: protein-coding
rs174537 in
TMEM258;MYRF gene and
Adenocarcinoma of large intestine
PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.
rs174528 in
TMEM258;MYRF gene and
Arachidonic acid measurement
PMID 26584805 2015 A genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population.
rs174537 in
TMEM258;MYRF gene and
COLORECTAL CANCER, SUSCEPTIBILITY TO, 1
PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.
PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
rs174537 in
TMEM258;MYRF gene and
COLORECTAL CANCER, SUSCEPTIBILITY TO, 10
PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.
rs174537 in
TMEM258;MYRF gene and
COLORECTAL CANCER, SUSCEPTIBILITY TO, 12
PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.
PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
rs174537 in
TMEM258;MYRF gene and
COLORECTAL CANCER, SUSCEPTIBILITY TO, 3
PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.
rs174528 in
TMEM258;MYRF gene and
Chronic Kidney Diseases
PMID 29545352 2018 Genome-Wide Association Studies of Metabolites in Patients with CKD Identify Multiple Loci and Illuminate Tubular Transport Mechanisms.
rs174537 in
TMEM258;MYRF gene and
Colorectal Carcinoma
PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.
PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
rs174537 in
TMEM258;MYRF gene and
Colorectal Neoplasms
PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.
PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
rs174537 in
TMEM258;MYRF gene and
Crohn Disease
PMID 26192919 2015 Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
rs174537 in
TMEM258;MYRF gene and
Fasting blood glucose measurement
PMID 22885924 2012 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
rs174537 in
TMEM258;MYRF gene and
Fasting blood sugar result
PMID 22885924 2012 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
rs174537 in
TMEM258;MYRF gene and
High density lipoprotein measurement
PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
rs174528 in
TMEM258;MYRF gene and
Kidney Failure, Chronic
PMID 29545352 2018 Genome-Wide Association Studies of Metabolites in Patients with CKD Identify Multiple Loci and Illuminate Tubular Transport Mechanisms.
rs174537 in
TMEM258;MYRF gene and
Malignant neoplasm of large intestine
PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.
rs174537 in
TMEM258;MYRF gene and
Malignant tumor of colon
PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.
PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
rs108499 in
TMEM258;MYRF gene and
Phospholipid measurement
PMID 21829377 2011 Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.
rs174536 in
TMEM258;MYRF gene and
RESTING HEART RATE
PMID 27798624 2016 Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.
PMID 29769521 2018 Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system.
rs108499 in
TMEM258;MYRF gene and
Serum albumin measurement
PMID 23281178 2013 A genome-wide assessment of variability in human serum metabolism.
PMID 22286219 2012 Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
rs174537 in
TMEM258;MYRF gene and
Triglycerides measurement
PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
PMID 19074352 2008 A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection.