Gene: TMEM258

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

Gene: MYRF

Alternate names for this Gene: 11orf9|C11orf9|CUGS|MMERV|MRF|Ndt80|pqn-47

Gene Summary: This gene encodes a transcription factor that is required for central nervous system myelination and may regulate oligodendrocyte differentiation. It is thought to act by increasing the expression of genes that effect myelin production but may also directly promote myelin gene expression. Loss of a similar gene in mouse models results in severe demyelination. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 11

Location in Chromosome : 11q12.2

Description of this Gene: myelin regulatory factor

Type of Gene: protein-coding

rs174537 in TMEM258;MYRF gene and Adenocarcinoma of large intestine PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

rs174528 in TMEM258;MYRF gene and Arachidonic acid measurement PMID 26584805 2015 A genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population.

rs174537 in TMEM258;MYRF gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

rs174537 in TMEM258;MYRF gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 10 PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

rs174537 in TMEM258;MYRF gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 12 PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

rs174537 in TMEM258;MYRF gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 3 PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

rs174528 in TMEM258;MYRF gene and Chronic Kidney Diseases PMID 29545352 2018 Genome-Wide Association Studies of Metabolites in Patients with CKD Identify Multiple Loci and Illuminate Tubular Transport Mechanisms.

rs174537 in TMEM258;MYRF gene and Colorectal Carcinoma PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

rs174537 in TMEM258;MYRF gene and Colorectal Neoplasms PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

rs174537 in TMEM258;MYRF gene and Crohn Disease PMID 26192919 2015 Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.

rs174537 in TMEM258;MYRF gene and Fasting blood glucose measurement PMID 22885924 2012 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.

rs174537 in TMEM258;MYRF gene and Fasting blood sugar result PMID 22885924 2012 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.

rs174537 in TMEM258;MYRF gene and High density lipoprotein measurement PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.

rs174528 in TMEM258;MYRF gene and Kidney Failure, Chronic PMID 29545352 2018 Genome-Wide Association Studies of Metabolites in Patients with CKD Identify Multiple Loci and Illuminate Tubular Transport Mechanisms.

rs174537 in TMEM258;MYRF gene and Malignant neoplasm of large intestine PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

rs174537 in TMEM258;MYRF gene and Malignant tumor of colon PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

rs108499 in TMEM258;MYRF gene and Phospholipid measurement PMID 21829377 2011 Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.

rs174536 in TMEM258;MYRF gene and RESTING HEART RATE PMID 27798624 2016 Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.

PMID 29769521 2018 Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system.

rs108499 in TMEM258;MYRF gene and Serum albumin measurement PMID 23281178 2013 A genome-wide assessment of variability in human serum metabolism.

PMID 22286219 2012 Genome-wide association study identifies multiple loci influencing human serum metabolite levels.

rs174537 in TMEM258;MYRF gene and Triglycerides measurement PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.

PMID 19074352 2008 A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection.