Gene: TNFAIP3

Alternate names for this Gene: A20|AISBL|OTUD7C|TNFA1P2

Gene Summary: This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene.

Gene is located in Chromosome: 6

Location in Chromosome : 6q23.3

Description of this Gene: TNF alpha induced protein 3

Type of Gene: protein-coding

Gene: WAKMAR2

Alternate names for this Gene:

Gene Summary:

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rs5029924 in TNFAIP3;WAKMAR2 gene and Lupus Erythematosus, Systemic PMID 27193031 2017 A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic lupus erythematosus.

rs5029924 in TNFAIP3;WAKMAR2 gene and Rheumatoid Arthritis PMID 27193031 2017 A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic lupus erythematosus.