Gene: TRIM2
Alternate names for this Gene: CMT2R|RNF86
Gene Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants.
Gene is located in Chromosome: 4
Location in Chromosome : 4q31.3
Description of this Gene: tripartite motif containing 2
Type of Gene: protein-coding