Gene: TSPAN16

Alternate names for this Gene: TM-8|TM4-B|TM4SF16

Gene Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein might couple to signal transduction pathways and possibly modulate cellular activation and adhesion in haemopoietic and neural tissue. Several transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 19

Location in Chromosome : 19p13.2

Description of this Gene: tetraspanin 16

Type of Gene: protein-coding

rs322144 in TSPAN16 gene and Breast Carcinoma PMID 29058716 2017 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.

rs56121005 in TSPAN16 gene and High density lipoprotein measurement PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.