Gene: UGT1A10

Alternate names for this Gene: GNT1|UDPGT|UGT-1A|UGT-1J|UGT1|UGT1-01|UGT1-10|UGT1.1|UGT1.10|UGT1A|UGT1A1|UGT1J|hUG-BR1

Gene Summary: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines.

Gene is located in Chromosome: 2

Location in Chromosome : 2q37.1

Description of this Gene: UDP glucuronosyltransferase family 1 member A10

Type of Gene: protein-coding

Gene: UGT1A8

Alternate names for this Gene: GNT1|UDPGT|UDPGT 1-8|UGT-1A|UGT-1H|UGT1|UGT1-01|UGT1-08|UGT1.1|UGT1.8|UGT1A|UGT1A1|UGT1A8S|UGT1H|hUG-BR1

Gene Summary: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids.

Gene is located in Chromosome: 2

Location in Chromosome : 2q37.1

Description of this Gene: UDP glucuronosyltransferase family 1 member A8

Type of Gene: protein-coding

rs10929251 in UGT1A10;UGT1A8 gene and Bilirubin level result PMID 19414484 2009 Genome-wide association meta-analysis for total serum bilirubin levels.

PMID 19419973 2009 Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.

PMID 23371916 2013 A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population.

PMID 23642732 2013 Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study.

rs10929251 in UGT1A10;UGT1A8 gene and Bilirubin measurement PMID 19414484 2009 Genome-wide association meta-analysis for total serum bilirubin levels.

PMID 23371916 2013 A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population.

PMID 19419973 2009 Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.

PMID 23642732 2013 Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study.

rs11892031 in UGT1A10;UGT1A8 gene and Carcinoma of bladder PMID 20972438 2010 In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1.

PMID 24163127 2014 Genome-wide association study identifies multiple loci associated with bladder cancer risk.

rs11892031 in UGT1A10;UGT1A8 gene and Malignant neoplasm of urinary bladder PMID 20972438 2010 In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1.

PMID 24163127 2014 Genome-wide association study identifies multiple loci associated with bladder cancer risk.

rs2602374 in UGT1A10;UGT1A8 gene and Serum albumin measurement PMID 23281178 2013 A genome-wide assessment of variability in human serum metabolism.