Gene: WNT10A

Alternate names for this Gene: OODD|SSPS|STHAG4

Gene Summary: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region.

Gene is located in Chromosome: 2

Location in Chromosome : 2q35

Description of this Gene: Wnt family member 10A

Type of Gene: protein-coding

rs121908120 in WNT10A gene and Acne Vulgaris PMID 30542056 2018 Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne.

rs7349332 in WNT10A gene and Alopecia PMID 28196072 2017 Genetic prediction of male pattern baldness.

rs7349332 in WNT10A gene and Alopecia, Androgenetic, 1 PMID 29146897 2017 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

rs7349332 in WNT10A gene and Alopecia, Androgenetic, 2 PMID 29146897 2017 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

rs7349332 in WNT10A gene and Alopecia, Androgenetic, 3 PMID 29146897 2017 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

rs7349332 in WNT10A gene and Alopecia, Male Pattern PMID 29146897 2017 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

rs7349332 in WNT10A gene and Androgenetic Alopecia PMID 29146897 2017 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

rs121908120 in WNT10A gene and Central corneal thickness PMID 29760442 2018 Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases.

PMID 30894546 2019 Sequence variation at ANAPC1 accounts for 24% of the variability in corneal endothelial cell density.

rs116135467 in WNT10A gene and Chronic Obstructive Airway Disease PMID 26634245 2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.

rs121908120 in WNT10A gene and Dental caries PMID 31235808 2019 Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data.

rs121908120 in WNT10A gene and Developmental absence of tooth PMID 29364747 2018 Rare and Common Variants Conferring Risk of Tooth Agenesis.

rs121908120 in WNT10A gene and Hypodontia PMID 29364747 2018 Rare and Common Variants Conferring Risk of Tooth Agenesis.

rs121908120 in WNT10A gene and Hypodontia Oligodontia with Orofacial Cleft PMID 29364747 2018 Rare and Common Variants Conferring Risk of Tooth Agenesis.

rs121908120 in WNT10A gene and Odontoonychodermal dysplasia PMID 24458874 2014 Tricho-odonto-onycho-dermal dysplasia and WNT10A mutations.

PMID 17847007 2007 Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia.

PMID 28589954 2017 WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation.

PMID 19559398 2009 WNT10A mutations are a frequent cause of a broad spectrum of ectodermal dysplasias with sex-biased manifestation pattern in heterozygotes.

PMID 19471313 2009 WNT10A missense mutation associated with a complete odonto-onycho-dermal dysplasia syndrome.

PMID 24902757 2014 Clinical features and WNT10A mutations in seven unrelated cases of Schöpf-Schulz-Passarge syndrome.

PMID 22670871 2013 Late diagnosis of ectodermal dysplasia syndrome.

PMID 21143469 2011 Two families confirm Schöpf-Schulz-Passarge syndrome as a discrete entity within the WNT10A phenotypic spectrum.

PMID 23167694 2013 Nucleotide variants of genes encoding components of the Wnt signalling pathway and the risk of non-syndromic tooth agenesis.

PMID 20163410 2010 Phenotypic variability associated with WNT10A nonsense mutations.

PMID 20979233 2011 Only four genes (EDA1, EDAR, EDARADD, and WNT10A) account for 90% of hypohidrotic/anhidrotic ectodermal dysplasia cases.

PMID 28981473 2017 Novel EDA or EDAR Mutations Identified in Patients with X-Linked Hypohidrotic Ectodermal Dysplasia or Non-Syndromic Tooth Agenesis.

rs121908120 in WNT10A gene and Oligodontia PMID 29364747 2018 Rare and Common Variants Conferring Risk of Tooth Agenesis.

rs7349332 in WNT10A gene and Other alopecia PMID 29146897 2017 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

rs121908120 in WNT10A gene and Reduced number of teeth PMID 25629078 2015 Taurodontism, variations in tooth number, and misshapened crowns in Wnt10a null mice and human kindreds.

rs372993798 in WNT10A gene and SCHOPF-SCHULZ-PASSARGE SYNDROME (disorder) PMID 19559398 2009 WNT10A mutations are a frequent cause of a broad spectrum of ectodermal dysplasias with sex-biased manifestation pattern in heterozygotes.

PMID 21143469 2011 Two families confirm Schöpf-Schulz-Passarge syndrome as a discrete entity within the WNT10A phenotypic spectrum.

rs121908120 in WNT10A gene and TOOTH AGENESIS, SELECTIVE, 4 (disorder) PMID 29178643 2017 Role of WNT10A in failure of tooth development in humans and zebrafish.

PMID 20979233 2011 Only four genes (EDA1, EDAR, EDARADD, and WNT10A) account for 90% of hypohidrotic/anhidrotic ectodermal dysplasia cases.

PMID 24311251 2014 WNT10A mutations also associated with agenesis of the maxillary permanent canines, a separate entity.

PMID 27657131 2016 Eight Mutations of Three Genes (EDA, EDAR, and WNT10A) Identified in Seven Hypohidrotic Ectodermal Dysplasia Patients.

PMID 22581971 2012 Mutations in WNT10A are present in more than half of isolated hypodontia cases.

PMID 23401279 2013 Mutations in WNT10A are frequently involved in oligodontia associated with minor signs of ectodermal dysplasia.

PMID 24449199 2014 WNT10A mutations account for ¼ of population-based isolated oligodontia and show phenotypic correlations.

PMID 21484994 2011 WNT10A and isolated hypodontia.

PMID 19559398 2009 WNT10A mutations are a frequent cause of a broad spectrum of ectodermal dysplasias with sex-biased manifestation pattern in heterozygotes.

PMID 21143469 2011 Two families confirm Schöpf-Schulz-Passarge syndrome as a discrete entity within the WNT10A phenotypic spectrum.

PMID 19471313 2009 WNT10A missense mutation associated with a complete odonto-onycho-dermal dysplasia syndrome.

PMID 22670871 2013 Late diagnosis of ectodermal dysplasia syndrome.

PMID 24902757 2014 Clinical features and WNT10A mutations in seven unrelated cases of Schöpf-Schulz-Passarge syndrome.

PMID 20163410 2010 Phenotypic variability associated with WNT10A nonsense mutations.

PMID 23167694 2013 Nucleotide variants of genes encoding components of the Wnt signalling pathway and the risk of non-syndromic tooth agenesis.

PMID 28981473 2017 Novel EDA or EDAR Mutations Identified in Patients with X-Linked Hypohidrotic Ectodermal Dysplasia or Non-Syndromic Tooth Agenesis.

rs121908120 in WNT10A gene and TOOTH AGENESIS, SELECTIVE, 9 PMID 29364747 2018 Rare and Common Variants Conferring Risk of Tooth Agenesis.

rs121908120 in WNT10A gene and Tooth Agenesis, Familial PMID 29364747 2018 Rare and Common Variants Conferring Risk of Tooth Agenesis.

rs121908120 in WNT10A gene and Tooth Agenesis, Selective, With Orofacial Cleft PMID 29364747 2018 Rare and Common Variants Conferring Risk of Tooth Agenesis.

rs121908120 in WNT10A gene and Tooth development and eruption disorder PMID 29364747 2018 Rare and Common Variants Conferring Risk of Tooth Agenesis.

rs116135467 in WNT10A gene and response to bronchodilator PMID 26634245 2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.