Gene: WNT2B
Alternate names for this Gene: WNT13
Gene Summary: This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants.
Gene is located in Chromosome: 1
Location in Chromosome : 1p13.2
Description of this Gene: Wnt family member 2B
Type of Gene: protein-coding
rs1175646 in
WNT2B gene and
Adolescent idiopathic scoliosis
PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
rs3790604 in
WNT2B gene and
Cardiovascular Diseases
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
rs12037987 in
WNT2B gene and
Cerebrovascular accident
PMID 29531354 2018 Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
rs10776752 in
WNT2B gene and
Diastolic blood pressure
PMID 30487518 2018 Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
PMID 27618452 2016 The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.
PMID 29455858 2018 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.
rs7516521 in
WNT2B gene and
High density lipoprotein measurement
PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
rs10776752 in
WNT2B gene and
Hypertensive disease
PMID 30487518 2018 Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
rs10776752 in
WNT2B gene and
Mean blood pressure
PMID 30487518 2018 Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
rs351365 in
WNT2B gene and
Pancreatic carcinoma
PMID 26098869 2015 Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.
rs3790606 in
WNT2B gene and
Physical Activity Measurement
PMID 28448500 2017 Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
rs12037987 in
WNT2B gene and
Potassium measurement
PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
rs1175646 in
WNT2B gene and
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
rs7516521 in
WNT2B gene and
Serum HDL cholesterol measurement
PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
rs10776752 in
WNT2B gene and
Systolic Pressure
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
PMID 30487518 2018 Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
PMID 27618452 2016 The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.
PMID 29455858 2018 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.
PMID 30578418 2019 Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.
PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
rs6692731 in
WNT2B gene and
Triglycerides measurement
PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.