Gene: ZFHX3
Alternate names for this Gene: ATBF1|ATBT|C16orf47|ZFH-3|ZNF927
Gene Summary: This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene.
Gene is located in Chromosome: 16
Location in Chromosome : 16q22.2-q22.3
Description of this Gene: zinc finger homeobox 3
Type of Gene: protein-coding
rs34516333 in
ZFHX3 gene and
Anxiety Disorders
PMID 31123309 2019 A genome-wide association meta-analysis of prognostic outcomes following cognitive behavioural therapy in individuals with anxiety and depressive disorders.
rs2106261 in
ZFHX3 gene and
Atrial Fibrillation
PMID 22544366 2012 Meta-analysis identifies six new susceptibility loci for atrial fibrillation.
PMID 19597492 2009 Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)).
PMID 28416818 2017 Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.
PMID 28460022 2017 Korean atrial fibrillation network genome-wide association study for early-onset atrial fibrillation identifies novel susceptibility loci.
PMID 28416822 2017 Identification of six new genetic loci associated with atrial fibrillation in the Japanese population.
PMID 30061737 2018 Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
PMID 29892015 2018 Multi-ethnic genome-wide association study for atrial fibrillation.
PMID 29290336 2018 Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development.
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
PMID 19597491 2009 A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)).
rs7189864 in
ZFHX3 gene and
Autosomal dominant compelling helio ophthalmic outburst syndrome
PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.
rs6564524 in
ZFHX3 gene and
Body Height
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
rs4788694 in
ZFHX3 gene and
Body mass index
PMID 28892062 2017 Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
PMID 30108127 2018 A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.
rs7193343 in
ZFHX3 gene and
Cardiac embolism
PMID 26708676 2016 Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study.
rs12932445 in
ZFHX3 gene and
Cardioembolic stroke
PMID 29531354 2018 Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
rs12932445 in
ZFHX3 gene and
Cerebrovascular accident
PMID 29531354 2018 Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
PMID 23041239 2012 Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.
rs7190256 in
ZFHX3 gene and
Coronary heart disease
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
rs7190256 in
ZFHX3 gene and
Diabetes
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
rs7190256 in
ZFHX3 gene and
Diabetes Mellitus
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
rs7190256 in
ZFHX3 gene and
Diastolic blood pressure
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
rs1858800 in
ZFHX3 gene and
Glomerular Filtration Rate
PMID 31015462 2019 Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis.
PMID 31152163 2019 A catalog of genetic loci associated with kidney function from analyses of a million individuals.
rs7190256 in
ZFHX3 gene and
Glucose measurement
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
rs7190256 in
ZFHX3 gene and
Heart failure
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
rs7190256 in
ZFHX3 gene and
Hematocrit procedure
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
rs7190256 in
ZFHX3 gene and
High density lipoprotein measurement
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
rs1858800 in
ZFHX3 gene and
Hypospadias
PMID 25108383 2014 Genome-wide association analyses identify variants in developmental genes associated with hypospadias.
rs7193343 in
ZFHX3 gene and
Ischemic stroke
PMID 26708676 2016 Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study.
rs328317 in
ZFHX3 gene and
Leukemia, Myelocytic, Acute
PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.
rs7190256 in
ZFHX3 gene and
Malignant Neoplasms
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
rs8054028 in
ZFHX3 gene and
Polybrominated biphenyl measurement
PMID 28235828 2017 Independent Maternal and Fetal Genetic Effects on Midgestational Circulating Levels of Environmental Pollutants.
rs7190256 in
ZFHX3 gene and
Serum total cholesterol measurement
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
rs12930834 in
ZFHX3 gene and
Smoking
PMID 30643258 2019 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.
rs62055084 in
ZFHX3 gene and
Systolic Pressure
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
rs7190256 in
ZFHX3 gene and
Triglycerides measurement
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
rs12922127 in
ZFHX3 gene and
Vital capacity
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
rs12325540 in
ZFHX3 gene and
Weight Gain
PMID 31560688 2019 Using metabolite profiling to construct and validate a metabolite risk score for predicting future weight gain.
rs7190256 in
ZFHX3 gene and
elevated blood glucose level
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
rs417278 in
ZFHX3 gene and
mathematical ability
PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.