Gene: ZKSCAN4
Alternate names for this Gene: P1P373C6|ZNF307|ZNF427|ZSCAN36
Gene Summary:
Gene is located in Chromosome: 6
Location in Chromosome : 6p22.1
Description of this Gene: zinc finger with KRAB and SCAN domains 4
Type of Gene: protein-coding
rs967005 in
ZKSCAN4 gene and
Lupus Erythematosus, Systemic
PMID 24871463 2014 GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
rs2235359 in
ZKSCAN4 gene and
Rheumatoid Arthritis
PMID 19503088 2009 REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
rs1233710 in
ZKSCAN4 gene and
Schizophrenia
PMID 22037552 2011 We identified two susceptibility loci for schizophrenia at 6p21-p22.1 (rs1233710 in an intron of ZKSCAN4, P(combined) = 4.76 × 10(-11), odds ratio (OR) = 0.79; rs1635 in an exon of NKAPL, P(combined) = 6.91 × 10(-12), OR = 0.78; rs2142731 in an intron of PGBD1, P(combined) = 5.14 × 10(-10), OR = 0.79) and 11p11.2 (rs11038167 near the 5' UTR of TSPAN18, P(combined) = 1.09 × 10(-11), OR = 1.29; rs11038172, P(combined) = 7.21 × 10(-10), OR = 1.25; rs835784, P(combined) = 2.73 × 10(-11), OR = 1.27).
PMID 30285260 2019 Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.