Variant: rs1057519721 

    present in Gene: INSL6;JAK2
    present in Chromosome: 9
    Position on Chromosome: 5078360
    Alleles of this Variant: A/G

rs1057519721 in INSL6;JAK2 gene and Acute lymphoblastic leukemia with lymphomatous features PMID 19470474 2009 JAK mutations in high-risk childhood acute lymphoblastic leukemia.

PMID 22368270 2012 Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation.

PMID 18805579 2008 Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome.

PMID 22955920 2012 Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia.

rs1057519721 in INSL6;JAK2 gene and Myeloproliferative disease PMID 20585391 2010 JAK2 V617F constitutive activation requires JH2 residue F595: a pseudokinase domain target for specific inhibitors.