Variant: rs1057519730 

    present in Gene: MAP2K1
    present in Chromosome: 15
    Position on Chromosome: 66436786
    Alleles of this Variant: T/A;G

rs1057519730 in MAP2K1 gene and Neoplasms PMID 19915144 2009 MEK1 mutations confer resistance to MEK and B-RAF inhibition.

rs1057519730 in MAP2K1 gene and melanoma PMID 22588879 2012 Preexisting MEK1 exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors.

PMID 22197931 2011 Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma.