Variant: rs121434596 

    present in Gene: NRAS
    present in Chromosome: 1
    Position on Chromosome: 114716123
    Alleles of this Variant: C/A;G;T

rs121434596 in NRAS gene and Colorectal Neoplasms PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs121434596 in NRAS gene and Cutaneous Melanoma PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs121434596 in NRAS gene and Gastric Adenocarcinoma PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs121434596 in NRAS gene and Juvenile Myelomonocytic Leukemia PMID 24493721 2014 American Society of Clinical Oncology Expert Statement: collection and use of a cancer family history for oncology providers.

PMID 17332249 2007 Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations.

rs121434596 in NRAS gene and Leukemia, Myelocytic, Acute PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

PMID 19657110 2009 Recurring mutations found by sequencing an acute myeloid leukemia genome.

rs121434596 in NRAS gene and Lymphoma, Non-Hodgkin, Familial PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs121434596 in NRAS gene and MYELODYSPLASTIC SYNDROME PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs121434596 in NRAS gene and Medulloblastoma PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs121434596 in NRAS gene and Multiple Myeloma PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs121434596 in NRAS gene and Neoplasms PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

rs121434596 in NRAS gene and RAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISORDER PMID 17517660 2007 NRAS mutation causes a human autoimmune lymphoproliferative syndrome.

rs121434596 in NRAS gene and Transitional cell carcinoma of bladder PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs121434596 in NRAS gene and melanoma PMID 16291983 2005 Distinct sets of genetic alterations in melanoma.

PMID 18375819 2008 BRAF and NRAS mutations in melanoma: potential relationships to clinical response to HSP90 inhibitors.

PMID 18390968 2008 Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers.

PMID 20179705 2010 RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.

PMID 23414587 2013 MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study.

PMID 20130576 2010 RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.

PMID 23431193 2013 Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo.

PMID 8120410 1994 Ras mutations in human melanoma: a marker of malignant progression.

PMID 2674680 1989 N-ras mutations in human cutaneous melanoma from sun-exposed body sites.

PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.