PMID 28485404 2017 We also observed a genome-wide significant association in non-Hispanic whites between the previously reported SNP rs1229984 in ADH1B and both alcohol consumption phenotypes (OR=0.79, P=2.47 × 10<sup>-20</sup> for drinker status and beta=-0.19, P=1.91 × 10<sup>-35</sup> for drinks/week), which replicated in Hispanic/Latinos (OR=0.72, P=4.35 × 10<sup>-7</sup> and beta=-0.21, P=2.58 × 10<sup>-6</sup>, respectively).
rs1229984 in
ADH1B gene and
Alcohol-Induced Disorders
PMID 23456092 2013 Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication.
PMID 24166409 2014 Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.
PMID 31090166 2019 Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria.
PMID 30940813 2019 Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.
rs1229984 in
ADH1B gene and
Alcohol-Related Disorders
PMID 23456092 2013 Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication.
PMID 24166409 2014 Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.
PMID 31090166 2019 Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria.
PMID 30940813 2019 Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.
rs1229984 in
ADH1B gene and
Alcoholic Intoxication, Chronic
PMID 23456092 2013 In case-control analysis, ADH1B rs1229984 (H47R) showed the most significant association with the risk of AD (p = 2.63 × 10(-21), OR = 2.35).
PMID 24166409 2014 Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.
PMID 30940813 2019 Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.
PMID 31090166 2019 In the trans-ancestral meta-analysis, rs1229984 was associated with multiple phenotypes and two additional loci were genome-wide significant: rs61826952 (chromosome 1, DSM-IV AD, P = 8.42E-11); rs7597960 (chromosome 2, Time spent drinking, P = 1.22E-08).
rs1229984 in
ADH1B gene and
Blood urea nitrogen measurement
PMID 31152163 2019 A catalog of genetic loci associated with kidney function from analyses of a million individuals.
rs1229984 in
ADH1B gene and
Body mass index
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.