present in Gene: APP
present in Chromosome: 21
Position on Chromosome: 25897626
Alleles of this Variant: TC/GA
rs281865161 in
APP gene and
Alzheimer's Disease
PMID 23649480 2013 Swedish mutant APP suppresses osteoblast differentiation and causes osteoporotic deficit, which are ameliorated by N-acetyl-L-cysteine.
PMID 21335619 2011 Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation.
PMID 8810256 1996 Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice.