Variant: rs766432

present in Gene: BCL11A present in Chromosome: 2 Position on Chromosome: 60492835 Alleles of this Variant: C/A

rs766432 in BCL11A gene and Anemia, Sickle Cell PMID 23406172 2013 Genetic determinants of haemolysis in sickle cell anaemia.

PMID 25042611 2014 The genetics of hemoglobin A2 regulation in sickle cell anemia.

PMID 21326311 2011 Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.

rs766432 in BCL11A gene and Fetal hemoglobin determination PMID 17767159 2007 A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.

PMID 22936743 2012 Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans.

PMID 20018918 2010 Genome-wide association studies also validated a previously identified SNP (rs766432) in BCL11A, a gene known to affect fetal hemoglobin levels (P = 2.6E-21) and in Thailand and Hong Kong subjects.

PMID 27022141 2016 Original Research: A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease.

PMID 21326311 2011 Recently, BCL11A (zinc-finger protein) was identified as a regulator of HbF, and the strongest association signals were observed either directly for rs766432 or for correlated single-nucleotide polymorphisms (SNPs).

rs766432 in BCL11A gene and Hemoglobin A2 measurement PMID 25042611 2014 The genetics of hemoglobin A2 regulation in sickle cell anemia.

rs766432 in BCL11A gene and Hemoglobin E disease PMID 20183929 2010 A genome-wide association identified the common genetic variants influence disease severity in beta0-thalassemia/hemoglobin E.

rs766432 in BCL11A gene and Reticulocyte count (procedure) PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.