rs10172646 in BCL11A gene and Fetal hemoglobin determination

PMID 17767159 2007 A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

PMID 21326311 2011 Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.

PMID 22936743 2012 Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans.

PMID 18245381 2008 Among major variants affecting HbF levels, SNP rs11886868 in the BCL11A gene was strongly associated with this trait (P < 10(-35)).

PMID 25372704 2014 Genome wide association study of fetal hemoglobin in sickle cell anemia in Tanzania.

PMID 26366553 2015 Genome-wide association analyses based on whole-genome sequencing in Sardinia provide insights into regulation of hemoglobin levels.

PMID 20018918 2010 Genome-wide association studies also validated a previously identified SNP (rs766432) in BCL11A, a gene known to affect fetal hemoglobin levels (P = 2.6E-21) and in Thailand and Hong Kong subjects.

PMID 27022141 2016 Original Research: A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease.

PMID 21326311 2011 Recently, BCL11A (zinc-finger protein) was identified as a regulator of HbF, and the strongest association signals were observed either directly for rs766432 or for correlated single-nucleotide polymorphisms (SNPs).

rs11136613 in CSMD1 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs6037828 in CSNK2A1 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs1003586 in HBB gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs2105819 in HBD gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

PMID 21326311 2011 Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.

rs10837767 in HBE1;HBG2 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs11037866 in HBE1;HBG2;OR51B5 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs411732 in HBE1;OR51B5;HBG2 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs6578592 in HBG1 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs2855123 in HBG2 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

PMID 17767159 2007 A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.

PMID 21326311 2011 Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.

rs4910742 in HBG2;HBE1 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

PMID 21326311 2011 Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.

PMID 26366553 2015 Genome-wide association analyses based on whole-genome sequencing in Sardinia provide insights into regulation of hemoglobin levels.

rs10768980 in HBG2;HBE1;OR51B5 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

PMID 21326311 2011 Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.

rs1353735 in HBG2;OR51B5;HBE1 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs17359438 in HBG2;OR51Q1;HBE1;OR51B5 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs2471991 in HBG2;OR51Q1;OR51B5;HBE1 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs2541639 in HBM gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs1547247 in HBS1L gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

PMID 17767159 2007 A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.

PMID 26366553 2015 Genome-wide association analyses based on whole-genome sequencing in Sardinia provide insights into regulation of hemoglobin levels.

PMID 22936743 2012 Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans.

PMID 21326311 2011 Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.

rs6600143 in HBZ gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs11125841 in LOC102724142 gene and Fetal hemoglobin determination

PMID 17767159 2007 A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs4895441 in LOC105378010 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

PMID 22936743 2012 Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans.

PMID 21326311 2011 Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.

rs1186868 in LOC107985767 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs10838807 in LOC112268071;TRIM5;OR52Q1P gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs1318772 in MCC gene and Fetal hemoglobin determination

PMID 21326311 2011 Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.

rs243078 in MIR4432;MIR4432HG gene and Fetal hemoglobin determination

PMID 17767159 2007 A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs13027161 in MIR4432HG gene and Fetal hemoglobin determination

PMID 17767159 2007 A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

PMID 21326311 2011 Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.

rs243079 in MIR4432HG;MIR4432 gene and Fetal hemoglobin determination

PMID 17767159 2007 A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs12271916 in MMP26 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

PMID 21326311 2011 Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.

rs12279647 in MMP26;OR51A8P gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs12788102 in MMP26;OR51F1 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs17325567 in MMP26;OR51N1P gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs2412395 in MMP26;OR51S1 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs4758622 in NAP1L4 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs17525396 in NPRL3 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs12286144 in OLFM5P gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs17328565 in OR51A8P;MMP26 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs2340349 in OR51B5;HBE1;HBG2 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs11037417 in OR51B5;HBG2;HBE1 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs11037444 in OR51B5;HBG2;HBE1;OR51I1 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs5006884 in OR51B6;OR51B5;HBE1;HBG2 gene and Fetal hemoglobin determination

PMID 22936743 2012 Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans.

PMID 20018918 2010 Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster.

PMID 21326311 2011 Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.

rs1123991 in OR51E2 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs17328191 in OR51F2;MMP26 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs10836955 in OR51G1;MMP26 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs12802922 in OR51G2;MMP26 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs10837104 in OR51L1 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs11037191 in OR51M1;HBE1;OR51B5;HBG2 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs17227978 in OR51N1P;MMP26 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs2499957 in OR51P1P gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs7937649 in OR51V1 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

PMID 21326311 2011 Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.

rs1368697 in OR52B5P gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs2445335 in OR52E2 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs2647602 in OR52H2P gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs7128702 in OR52I2 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs2445271 in OR52J2P gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs2500012 in OR52J3 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs11039100 in OR52N2;TRIM5 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs10837513 in OR52Z1 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs7679 in PCIF1 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs720106 in RRM1 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs11030841 in STIM1 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs4369384 in SYT9 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs11039274 in TRIM5 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs11039508 in TRIM5;LOC112268071;OR52E5 gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

rs1044392 in UBQLNL gene and Fetal hemoglobin determination

PMID 18245381 2008 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.