Condition: Leukopenia


rs79206939 in FTO gene and Leukopenia PMID 27558924 2017 High-throughput targeted sequencing indicated that an <i>FTO</i> coding variant (rs79206939, p.A134T) linked to rs16957920 is associated with thiopurine-induced leukopenia.

rs117506642 in LOC105376755 gene and Leukopenia PMID 29923122 2018 NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study.

rs2916733 in MCPH1 gene and Leukopenia PMID 21799462 2011 The combined analysis indicated that rs2916733 in microcephalin 1 [combined PFisher min=2.27×10, odds ratio (OR)=2.74 with 95% confidence interval (CI)=1.96-3.83; the nonrisk genotype as reference] was significantly associated with epirubicin-induced leukopenia/neutropenia.

rs116855232 in NUDT15 gene and Leukopenia PMID 25108385 2014 We identified a nonsynonymous SNP in NUDT15 (encoding p.Arg139Cys) that was strongly associated with thiopurine-induced early leukopenia (odds ratio (OR) = 35.6; P(combined) = 4.88 × 10(-94)).

PMID 29923122 2018 We confirmed the association of NUDT15 p.Arg139Cys with leukopenia and alopecia (p = 2.20E-63, 1.32E-69, OR = 6.59, 12.1, respectively), and found a novel association with digestive symptoms (p = 6.39E-04, OR = 1.89).

PMID 27558924 2017 A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD.