Gene: FTO

Alternate names for this Gene: ALKBH9|BMIQ14|GDFD

Gene Summary: This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.

Gene is located in Chromosome: 16

Location in Chromosome : 16q12.2

Description of this Gene: FTO alpha-ketoglutarate dependent dioxygenase

Type of Gene: protein-coding

rs12149832 in FTO gene and Adolescent idiopathic scoliosis PMID 31417091 2019 Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese.

PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs11642015 in FTO gene and Age at menarche PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

PMID 25231870 2014 Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

PMID 21102462 2010 Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.

rs10521305 in FTO gene and Age at menopause PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs55872725 in FTO gene and Alcohol consumption PMID 29912962 2018 Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

rs11075992 in FTO gene and Alcohol-Induced Disorders PMID 30940813 2019 Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.

rs11075992 in FTO gene and Alcohol-Related Disorders PMID 30940813 2019 Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.

rs11075992 in FTO gene and Alcoholic Intoxication, Chronic PMID 30940813 2019 Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.

rs9939609 in FTO gene and Atrial Fibrillation PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs11642015 in FTO gene and Blood urea nitrogen measurement PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

PMID 31152163 2019 A catalog of genetic loci associated with kidney function from analyses of a million individuals.

rs55872725 in FTO gene and Body Fat Distribution PMID 30664634 2019 Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects.

rs113191842 in FTO gene and Body Weight PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

PMID 19079260 2009 Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.

PMID 17658951 2007 Within the FTO gene, rs9930506 showed the strongest association with BMI (p = 8.6 x10(-7)), hip circumference (p = 3.4 x 10(-8)), and weight (p = 9.1 x 10(-7)).

rs10680802 in FTO gene and Body mass index PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.

PMID 23563607 2013 Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.

PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

PMID 18454148 2008 Common variants near MC4R are associated with fat mass, weight and risk of obesity.

PMID 31453325 2019 Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank.

PMID 28892062 2017 Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.

PMID 22344221 2012 Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 26961502 2016 Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively.

PMID 26604143 2016 Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.

PMID 28443625 2017 Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

PMID 25953783 2015 A genome-wide association study of body mass index across early life and childhood.

PMID 24861553 2014 Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.

PMID 26426971 2015 The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

PMID 25673413 2015 Genetic studies of body mass index yield new insights for obesity biology.

PMID 30108127 2018 A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.

PMID 20935630 2010 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

PMID 30045251 2018 Causal association of body mass index with hypertension using a Mendelian randomization design.

PMID 28430825 2017 Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium.

PMID 23583978 2013 A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.

PMID 28448500 2017 Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

PMID 28270201 2017 Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants.

PMID 24064335 2014 Meta-analysis of genome-wide association data identifies novel susceptibility loci for obesity.

PMID 19079260 2009 Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.

PMID 22982992 2012 We report evidence that the single nucleotide polymorphism (SNP) rs7202116 at the FTO gene locus, which is known to be associated with obesity (as measured by mean BMI for each rs7202116 genotype), is also associated with phenotypic variability.

PMID 24348519 2013 EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children.

PMID 21037115 2011 In the combined analyses, a significant association was found between rs8050136, located in the first intron of the fat mass and obesity-associated (FTO) gene, and BMI (P = 4.97 × 10(-7)) and FFMI (P = 1.19 × 10(-7)).

PMID 17658951 2007 Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.

PMID 17434869 2007 A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.

PMID 19079261 2009 Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

PMID 19396169 2009 A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.

PMID 31513605 2019 Structural equation modeling for hypertension and type 2 diabetes based on multiple SNPs and multiple phenotypes.

PMID 23669352 2013 Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.

rs11075990 in FTO gene and Body mass index procedure PMID 23563607 2013 Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.

PMID 18454148 2008 Common variants near MC4R are associated with fat mass, weight and risk of obesity.

PMID 22344221 2012 Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.

PMID 19079261 2009 Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

PMID 23555315 2013 Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population.

PMID 23001569 2013 Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals.

PMID 24064335 2014 Meta-analysis of genome-wide association data identifies novel susceptibility loci for obesity.

PMID 24861553 2014 Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.

PMID 20935630 2010 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

PMID 24348519 2013 EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children.

PMID 22344219 2012 Meta-analysis identifies common variants associated with body mass index in east Asians.

PMID 23583978 2013 A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.

PMID 19079260 2009 Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.

PMID 22982992 2012 We report evidence that the single nucleotide polymorphism (SNP) rs7202116 at the FTO gene locus, which is known to be associated with obesity (as measured by mean BMI for each rs7202116 genotype), is also associated with phenotypic variability.

PMID 17434869 2007 A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.

PMID 23669352 2013 Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.

rs11075995 in FTO gene and Breast Carcinoma PMID 25751625 2015 Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.

PMID 23535733 2013 Genome-wide association studies identify four ER negative-specific breast cancer risk loci.

PMID 29059683 2017 Association analysis identifies 65 new breast cancer risk loci.

PMID 27117709 2016 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer.

PMID 23535729 2013 Large-scale genotyping identifies 41 new loci associated with breast cancer risk.

rs62033406 in FTO gene and Breast size PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs1558902 in FTO gene and C-reactive protein measurement PMID 27286809 2016 Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation.

PMID 30388399 2018 Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.

rs7187250 in FTO gene and Cardiovascular Diseases PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs9939609 in FTO gene and Cerebrovascular accident PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs8050136 in FTO gene and Chronic Obstructive Airway Disease PMID 21037115 2011 Genome-wide association analysis of body mass in chronic obstructive pulmonary disease.

rs8050136 in FTO gene and Coronary heart disease PMID 21347282 2011 Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.

PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs12596638 in FTO gene and Cutaneous Melanoma PMID 30429480 2018 Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.

rs9939609 in FTO gene and Diabetes PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs9939609 in FTO gene and Diabetes Mellitus PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs11075989 in FTO gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 22158537 2011 Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.

PMID 22885922 2012 Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.

PMID 20581827 2010 Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.

PMID 23300278 2013 Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.

PMID 26818947 2016 Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 30718926 2019 Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.

PMID 30054458 2018 Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.

PMID 17463249 2007 Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.

PMID 19056611 2009 In the "obese-type 2 diabetes" scan, FTO variants had the strongest type 2 diabetes effect (rs8050136: relative risk [RR] 1.49 [95% CI 1.34-1.66], P = 1.3 x 10(-13)), with only weak evidence for TCF7L2 (rs7901695 RR 1.21 [1.09-1.35], P = 0.001).

PMID 17463248 2007 A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.

PMID 28869590 2017 Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.

PMID 26961502 2016 Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively.

PMID 24509480 2014 Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

PMID 22693455 2012 Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.

PMID 17554300 2007 Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

PMID 21647700 2011 Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.

rs11642015 in FTO gene and Diastolic blood pressure PMID 29455858 2018 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.

PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs17817288 in FTO gene and Duration of sleep PMID 30846698 2019 Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates.

PMID 30804565 2019 Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways.

rs56094641 in FTO gene and Finding of Mean Corpuscular Hemoglobin PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs11075990 in FTO gene and Finding of body mass index PMID 23563607 2013 Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.

PMID 18454148 2008 Common variants near MC4R are associated with fat mass, weight and risk of obesity.

PMID 22344221 2012 Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.

PMID 24064335 2014 Meta-analysis of genome-wide association data identifies novel susceptibility loci for obesity.

PMID 19079261 2009 Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

PMID 23001569 2013 Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals.

PMID 23555315 2013 Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population.

PMID 20935630 2010 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

PMID 24861553 2014 Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.

PMID 24348519 2013 EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children.

PMID 22344219 2012 Meta-analysis identifies common variants associated with body mass index in east Asians.

PMID 23583978 2013 A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.

PMID 19079260 2009 Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.

PMID 22982992 2012 FTO genotype is associated with phenotypic variability of body mass index.

PMID 17434869 2007 A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.

PMID 23669352 2013 Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.

rs9939609 in FTO gene and Glucose measurement PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs121918214 in FTO gene and Growth Retardation, Developmental Delay, Coarse Facies, And Early Death PMID 22002720 2011 N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.

PMID 26697951 2016 FTO variant associated with malformation syndrome.

PMID 26378117 2016 Identification of a pathogenic FTO mutation by next-generation sequencing in a newborn with growth retardation and developmental delay.

PMID 19559399 2009 Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations.

rs9939609 in FTO gene and Heart failure PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs9939609 in FTO gene and Hematocrit procedure PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs1121980 in FTO gene and High density lipoprotein measurement PMID 28334899 2017 Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.

PMID 24097068 2013 Discovery and refinement of loci associated with lipid levels.

PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

PMID 27286809 2016 Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation.

PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.

PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs113191842 in FTO gene and Hip circumference PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

PMID 31453325 2019 Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank.

PMID 25673412 2015 New genetic loci link adipose and insulin biology to body fat distribution.

rs79206939 in FTO gene and Inflammatory Bowel Diseases PMID 27558924 2017 A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD.

rs7189997 in FTO gene and Kidney Failure, Chronic PMID 31178898 2019 Genetics of Chronic Kidney Disease Stages Across Ancestries: The PAGE Study.

rs113191842 in FTO gene and Lean body mass PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

PMID 30593698 2019 Genomics of body fat percentage may contribute to sex bias in anorexia nervosa.

PMID 28724990 2017 Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

rs8043757 in FTO gene and Leptin measurement PMID 26833098 2016 Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.

rs79206939 in FTO gene and Leukopenia PMID 27558924 2017 High-throughput targeted sequencing indicated that an <i>FTO</i> coding variant (rs79206939, p.A134T) linked to rs16957920 is associated with thiopurine-induced leukopenia.

rs9939609 in FTO gene and Malignant Neoplasms PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs12596638 in FTO gene and Malignant melanoma of skin of lower limb PMID 30429480 2018 Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.

rs12596638 in FTO gene and Malignant melanoma of skin of upper limb PMID 30429480 2018 Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.

rs11075995 in FTO gene and Malignant neoplasm of breast PMID 23535733 2013 Genome-wide association studies identify four ER negative-specific breast cancer risk loci.

PMID 23535729 2013 Large-scale genotyping identifies 41 new loci associated with breast cancer risk.

rs11642015 in FTO gene and Mean blood pressure PMID 30487518 2018 Interethnic analyses of blood pressure loci in populations of East Asian and European descent.

PMID 29912962 2018 Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

rs9940128 in FTO gene and Metabolic Syndrome X PMID 22399527 2012 Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.

rs56094641 in FTO gene and Microalbuminuria PMID 30566433 2018 A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.

rs10852521 in FTO gene and Obesity PMID 21935397 2011 Genome-wide population-based association study of extremely overweight young adults--the GOYA study.

PMID 21544081 2012 Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations.

PMID 23563607 2013 Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.

PMID 18159244 2007 Six single nucleotide polymorphisms (SNPs) in FTO (fat mass and obesity associated gene) within one linkage disequilibrium (LD) block including the GWA SNP rendering the lowest p-value (rs1121980; log-additive model: nominal p = 1.13 x 10(-7), corrected p = 0.0494; odds ratio (OR)(CT) 1.67, 95% confidence interval (CI) 1.22-2.27; OR(TT) 2.76, 95% CI 1.88-4.03) belonged to the 15 SNPs showing the strongest evidence for association with obesity.

PMID 23563609 2013 Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.

PMID 19151714 2009 Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.

PMID 20421936 2010 Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups.

PMID 21552555 2011 For the binary trait of obesity, we found 16 genome-wide significant signals within the FTO gene (strongest signal at rs17817449, P = 2.5 × 10(-12)).

PMID 18159244 2007 Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants.

PMID 21706003 2011 Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.

PMID 22484627 2012 A genome-wide association meta-analysis identifies new childhood obesity loci.

PMID 19553259 2009 Common body mass index-associated variants confer risk of extreme obesity.

rs9930333 in FTO gene and Osteoarthritis of hip PMID 30664745 2019 Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.

rs9930333 in FTO gene and Osteoarthritis, Knee PMID 30664745 2019 Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.

rs3751812 in FTO gene and Physical Activity Measurement PMID 28448500 2017 Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

PMID 29899525 2018 Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE.

rs1121980 in FTO gene and Polysomnography PMID 17658951 2007 Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.

rs1558902 in FTO gene and RDW - Red blood cell distribution width result PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 28957414 2017 Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.

rs1558902 in FTO gene and Red cell distribution width determination PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 28957414 2017 Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.

rs7195994 in FTO gene and Rheumatoid Arthritis PMID 30166627 2018 Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis.

rs12149832 in FTO gene and SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 PMID 31417091 2019 Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese.

PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs1121980 in FTO gene and Serum HDL cholesterol measurement PMID 24097068 2013 Discovery and refinement of loci associated with lipid levels.

PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs9939609 in FTO gene and Serum total cholesterol measurement PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs1558902 in FTO gene and Smoking PMID 28443625 2017 Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

rs1421085 in FTO gene and Smoking Behaviors PMID 20418888 2010 Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.

rs11642015 in FTO gene and Sodium measurement PMID 31409800 2019 GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits.

rs11642015 in FTO gene and Systolic Pressure PMID 29455858 2018 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.

PMID 30487518 2018 Interethnic analyses of blood pressure loci in populations of East Asian and European descent.

PMID 29912962 2018 Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs1121980 in FTO gene and Triglycerides measurement PMID 24097068 2013 Discovery and refinement of loci associated with lipid levels.

PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.

PMID 28334899 2017 Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.

PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs62033406 in FTO gene and Uric acid measurement (procedure) PMID 31578528 2019 Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.

rs7206790 in FTO gene and Urolithiasis PMID 30975718 2019 Novel Risk Loci Identified in a Genome-Wide Association Study of Urolithiasis in a Japanese Population.

rs10852521 in FTO gene and Waist Circumference PMID 19557197 2009 NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium.

PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

PMID 31453325 2019 Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank.

PMID 25673412 2015 New genetic loci link adipose and insulin biology to body fat distribution.

rs11075985 in FTO gene and Waist-Hip Ratio PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

PMID 25673412 2015 New genetic loci link adipose and insulin biology to body fat distribution.

PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

PMID 17658951 2007 Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.

PMID 19396169 2009 A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.

rs9972653 in FTO gene and White Blood Cell Count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs8050136 in FTO gene and adiposity PMID 21706003 2011 Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.

rs1421085 in FTO gene and body fat percentage (physical finding) PMID 30593698 2019 Genomics of body fat percentage may contribute to sex bias in anorexia nervosa.

PMID 26833246 2016 New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

PMID 28270201 2017 Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants.

PMID 31453325 2019 Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank.

rs9939609 in FTO gene and elevated blood glucose level PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs16953002 in FTO gene and melanoma PMID 28212542 2017 Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma.

PMID 23455637 2013 A variant in FTO shows association with melanoma risk not due to BMI.